| Description | Phosphoribosylglycinamide synthetase ( ) (GARS) (phosphoribosylamine glycine ligase) [ ] catalyses the second step in thede novobiosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide: ATP + 5-phosphoribosylamine + glycine = ADP + Pi+ 5'-phosphoribosylglycinamide In bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). In yeast, GARS is part of a bifunctional enzyme (encoded by the ADE5,7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) [ ]. In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART [].This signature pattern identifies a highly conserved octapeptide. | Name | Phosphoribosylglycinamide synthetase, conserved site |
| Short Name | PRibGlycinamide_synth_CS | Type | Conserved_site |
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