| Description | The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression [ ]. TET proteins, including TET1/2/3, convert 5-methylcytosine to 5-hydroxymethylcytosine. They can also convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine []. They play roles in epigenetic regulation [, ]. Human TET2 mutations have been linked to various leukaemias. TET2 and TET3 interact with O-GlcNAc transferase (OGT) and promotes OGT-mediated GlcNAcylation []. The double epigenetic modifications on both DNA and histones by TET2 and OGT coordinate together for the regulation of gene transcription [].This entry represents the oxygenase domain of TET proteins. | Name | Methylcytosine dioxygenase TET1-3, oxygenase domain |
| Short Name | TET_oxygenase | Type | Domain |
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