| Description | Diadenylate cyclase catalyses the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a signaling compound secreted into the host's cytosol by bacterial pathogens, such as Listeria monocytogenes. This compound triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity [ ]. Apart from a role in the establishment of bacterial infection, c-di-AMP seems to be involved in coordinating bacterial growth, cell wall stability, and responses to stress [].Most bacteria possess one diadenylate cyclase (DAC) enzyme (CdaA, also called YbbP and DacA), while Bacillus subtilis has two additional DACs (CdaS, also called YojJ and DacB) and DisA [ , ]. This entry includes CdaA from B.subtilis, which produces the c-di-AMP required for cell wall homeostasis but harmful in excess [, ]. | Name | Diadenylate cyclase CdaA |
| Short Name | CdaA | Type | Family |
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