| Description | The exact function of the Hepatitis C non-structural 5A (NS5A) protein is not known, but it is an active component of the replicase, regulates replication and modulates a range of cellular processes including innate immunity and dysregulated cell growth. NS5A is organised into three domains, labelled I, II and III. Domain I contains a zinc-binding motif and an amphipathic N-terminal helix which promotes membrane association. Mutations disrupting either the membrane anchor or zinc binding are lethal for RNA replication [ , ].This entry represents the 1a domain of NS5A. It binds zinc, which is thought to be crucial for fold maintenance and is essential for replicase function [ ]. | Name | NS5A domain 1a superfamily |
| Short Name | NS5A_1a_sf | Type | Homologous_superfamily |
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