| Description | TNF receptor 19, also known as toxicity and JNK inducer (TAJ) and TROY, is highly expressed during embryonic development, where it may act as a regulator of cell activation and cell death [ ]. In adult tissues, the receptor is expressed in the central nervous system, and may mediate the inhibitory effects of myelin upon axon regeneration [].The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of an extended rod-like structure, responsible for ligand binding [].Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences [ ]. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [, ]. | Name | Tumour necrosis factor receptor 19 |
| Short Name | TNFR_19 | Type | Family |
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