| Description | This entry represents the Ras-associating (RA) domain of ARHGAP20.ARHGAP20 (also known as RARhoGAP/Rho GTPase-activating protein 20) is thought to function in rearrangements of the cytoskeleton and cell signalling events that occur during spermatogenesis [ ]. ARHGAP20 was also shown to be activated by Rap1 and to induce inactivation of Rho, resulting in the neurite outgrowth []. Recent findings show that ARHGAP20, even although it is located in the middle of the MDR on 11q22-23, is expressed at higher levels in chronic lymphocytic leukemia patients with 11q22-23 and/or 13q14 deletions and its expression pattern suggests a functional link between cases with 11q22-23 and 13q14 deletions []. ARHGAP20 contains a PH domain, a Ras-associating domain, a Rho-GAP domain, and ANXL repeats. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarised [, , ]. | Name | ARHGAP20, Ras-associating domain |
| Short Name | ARHGAP20_RA | Type | Domain |
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