Description | Involucrin [ , ] is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane [] functioning as a glutamyl donor during assembly of the cornified envelope.This entry represents the signature pattern for involucrin, which is located at the N-terminal extremity of these proteins. | Name | Involucrin, conserved site |
Short Name | Involucrin_CS | Type | Conserved_site |